The role of temperature in forming sol-gel biocomposites containing polydopamine.
The role of temperature in forming sol-gel biocomposites containing polydopamine.
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DOI：
10.1039/c4tb00884g
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发表时间：
2014-11-28
期刊：
影响因子：
--
通讯作者：
You W
中科院分区：
文献类型：
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作者：
Dyke JC;Hu H;Lee DJ;Ko CC;You W
为了进一步提高羟基磷灰石-明胶（HAp-Gel）和硅氧烷溶胶-凝胶反应制备的生物陶瓷的物理强度和生物医学应用性，我们将贻贝粘合剂激发的聚多巴胺（PD）引入到我们的基于硅氧烷交联的HAp-Gel的原始复合材料中。令人惊讶的是，随着PD的加入，我们观察到加工条件和温度对这些材料的结构和性能起着重要作用。一个系统的研究，以调查这种温度依赖性的行为披露，在溶胶-凝胶过程中的硅烷的交联速率显着的温度的影响，而多巴胺的聚合反应只显示出轻微的温度依赖性。有了这一发现，我们报告了一个创新的热处理这些生物复合材料的设计和应用。
To further improve the physical strength and biomedical applicability of bioceramicsbuilt on hydroxyapatite-gelatin (HAp-Gel) and siloxane sol-gel reactions, we incorporated mussel adhesive inspired polydopamine (PD) into our original composite based on HAp-Gel cross-linked with siloxane. Surprisingly, with the addition of PD, we observed that the processing conditions and temperatures play an important role in the structure and performance of these materials. A systematic study to investigate this temperature dependence behavior discloses that the rate of crosslinking of silane during the sol-gel process is significantly influenced by the temperature, whereas the polymerization of the dopamine only shows minor temperature dependence. With this discovery, we report an innovative thermal process for the design and application of these biocomposites.