Antifungal piperolides from Piper malacophyllum (Prels) C. DC.
Antifungal piperolides from Piper malacophyllum (Prels) C. DC.
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DOI：
10.1590/s0103-50532005000200005
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发表时间：
2005-04-01
影响因子：
1.4
通讯作者：
Kato, Massuo J.
中科院分区：
文献类型：
--
作者：
Lago, João Henrique G.;Tanizaki, Tatiane M.;Kato, Massuo J.
Bioactivity- guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6- dimethoxy- 5- E- phenylbutenolide ( 1) and 4,6- dimethoxy- 5- Z- phenylbutenolide ( 2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/ 1.0 mu g ( 1) and 5.0/ 10.0 mu g ( 2), respectively.
