Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia
Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia
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DOI：
10.1038/nm1011
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发表时间：
2004-04-01
期刊：
影响因子：
82.9
通讯作者：
Rudy, Y
中科院分区：
文献类型：
--
作者：
Ramanathan, C;Ghanem, RN;Rudy, Y
全世界每年有700多万人死于心律失常（心律失常），还有更多的人残疾。然而，目前还没有影像学方法来识别有风险的患者，提供准确的诊断和指导治疗。标准的诊断技术，如心电图（ECG）只能在体表上提供低分辨率的心电活动投影。在这里，我们展示了一种称为心电图成像（ECGI）的新成像方式在人类中的成功应用，它可以对心脏中的心电活动进行无创成像。在ECGI中，多电极背心记录224个体表心电图；然后利用计算机断层扫描（CT）的几何信息和数学算法在心脏表面重建电势、电图和等时线。我们提供了ECGI在(i)正常心脏（ii）传导障碍心脏（右束分支阻滞）（iii）右或左心室起搏引起的局灶激活以及（iv）心房扑动期间的应用实例。
Over 7 million people worldwide die annually from erratic heart rhythms (cardiac arrhythmias), and many more are disabled. Yet there is no imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy. Standard diagnostic techniques such as the electrocardiogram (ECG) provide only low-resolution projections of cardiac electrical activity on the body surface. Here we demonstrate the successful application in humans of a new imaging modality called electrocardiographic imaging (ECGI), which noninvasively images cardiac electrical activity in the heart. In ECGI, a multielectrode vest records 224 body-surface electrocardiograms; electrical potentials, electrograms and isochrones are then reconstructed on the heart's surface using geometrical information from computed tomography (CT) and a mathematical algorithm. We provide examples of ECGI application during atrial and ventricular activation and ventricular repolarization in (i) normal heart (ii) heart with a conduction disorder (right bundle branch block) (iii) focal activation initiated by right or left ventricular pacing, and (iv) atrial flutter.