Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.
Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.
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角膜缘干细胞缺乏症的新兴治疗策略
DOI：
10.1155/2018/7894647
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发表时间：
2018
影响因子：
1.9
通讯作者：
Lavker RM
中科院分区：
文献类型：
--
作者：
Dong Y;Peng H;Lavker RM
角膜缘上皮干细胞（LESC）的鉴定和表征已被证明是前眼表生物学的一项重大成就。这些细胞已被证明是角膜缘上皮基底细胞的亚群，其充当角膜上皮的祖细胞群。LESC已被证明在维持角膜上皮稳态中起重要作用。许多眼表疾病，包括内源性（例如，干燥综合征）或外源性（例如，碱或热烧伤）损伤LESC，可导致角膜缘干细胞缺陷（LSCD）。LSCD的特征在于结膜源性上皮细胞的过度生长、角膜新生血管形成和慢性炎症，最终导致失明。LSCD的治疗一直具有挑战性，尤其是双侧全LSCD。最近，LESC研究的进展导致了治疗LSCD的新的治疗方法，如培养的角膜缘上皮移植。这些新的治疗方法已证明对LSCD患者的眼表重建和视力恢复有效。然而，它们都有自己的局限性。在这里，我们描述了LSCD治疗的现状，并讨论了现有治疗方式的优点和缺点。
Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology. These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium. LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis. Many ocular surface diseases, including intrinsic (e.g., Sjogren's syndrome) or extrinsic (e.g., alkali or thermal burns) insults, which impair LESCs, can lead to limbal stem cell deficiency (LSCD). LSCD is characterized by an overgrowth of conjunctival-derived epithelial cells, corneal neovascularization, and chronic inflammation, eventually leading to blindness. Treatment of LSCD has been challenging, especially in bilateral total LSCD. Recently, advances in LESC research have led to novel therapeutic approaches for treating LSCD, such as transplantation of the cultured limbal epithelium. These novel therapeutic approaches have demonstrated efficacy for ocular surface reconstruction and restoration of vision in patients with LSCD. However, they all have their own limitations. Here, we describe the current status of LSCD treatment and discuss the advantages and disadvantages of the available therapeutic modalities.
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同种异体培养式角膜缘上皮移植治疗严重眼部烧伤引起的睑缘联合的远期疗效
影响因子：
2
作者：
Cheng J;Zhai H;Wang J;Duan H;Zhou Q
通讯作者：
Zhou Q
DOI：
10.1083/jcb.200703003
发表时间：
2007-06-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
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De Luca M
影响因子：
4.2
作者：
Basu, Sayan;Ali, Md Hasnat;Sangwan, Virender S.
通讯作者：
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影响因子：
13.7
作者：
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通讯作者：
James, SE
影响因子：
2.8
作者：
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通讯作者：
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