C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity.
C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity.
复制标题
皮马印第安人和白种人的 C 肽和胰岛素分泌：在各种胰岛素浓度和肥胖情况下的恒定分数肝提取。
DOI：
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发表时间：
1979
影响因子：
5.8
通讯作者：
P. Bennett
中科院分区：
文献类型：
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作者：
P. Savage;E. Flock;M. Mako;P. Blix;A. Rubenstein;P. Bennett
在口服葡萄糖耐量试验期间，测量外周血清胰岛素和C肽浓度在10个非糖尿病的皮马印第安人和10个非糖尿病的白人不同程度的肥胖。尽管与高加索人相比，印度人的胰岛素和C-肽水平均升高（p <0.05），但通过比较C-肽与胰岛素的比值测量的肝脏胰岛素提取在两组的胰岛素浓度范围内相似。C肽与胰岛素的比值与肥胖程度无关。这些研究表明，皮马印第安人和肥胖受试者的外周高胰岛素血症通常是由于胰腺分泌过多，而不是由于肝脏提取胰岛素减少。
Peripheral serum insulin and C-peptide concentrations during oral glucose tolerance tests were measured in 10 nondiabetic Pima Indians and 10 nondiabetic Caucasians with varying degrees of obesity. Although both insulin and C-peptide levels were elevated in the Indians compared to the Caucasians (p less than 0.05), hepatic insulin extraction, measured by comparing the C-peptide to insulin ratios, was similar over a wide range of insulin concentrations in both groups. The ratios of C-peptide to insulin were independent of the degree of obesity. These studies indicate that the peripheral hyperinsulinemia in Pima Indians and obese subjects is due in general to pancreatic hypersecretion rather than to diminished hepatic extraction of insulin.