Triterpenoids and Saponins from the Leaves of Uncaria hirsuta
Triterpenoids and Saponins from the Leaves of Uncaria hirsuta
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DOI：
10.1002/hlca.200800312
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发表时间：
2009-04
影响因子：
1.8
通讯作者：
Wen-Bo Xin;G. Chou;Zheng-Tao Wang
中科院分区：
文献类型：
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作者：
Wen-Bo Xin;G. Chou;Zheng-Tao Wang
本文报道了三个新的三萜类化合物：（3β）-3-羟基-27-降油酸-13（28）-内酯（1），（22α）-22-羟基-3-氧代-乌苏-12-烯-27，28-二酸（4），（3β）-3-（β-D-吡喃葡萄糖基氧基）-12-氧代对苯醌酸β-D-吡喃葡萄糖基酯（7），以及四种已知化合物，焦辛胆酸乙酯（2），焦辛胆酸（3），从毛钩藤（Uncaria hirsutaHaviland）叶的乙醇提取物中分离得到2个化合物：（1）奎宁酸（5）和（3β）-3-（β-D-喹啉吡喃糖氧基）焦肉桂胆酸β-D-吡喃葡萄糖酯（6）。通过高分辨电喷雾质谱（HR-ESI-MS）和二维核磁共振（2D-NMR）等波谱分析手段确定了它们的结构。1的构型通过X射线分析确认; 2是人工产物，如通过HPLC和LC/MS分析所验证的。
Three new triterpenoids, (3β)-3-hydroxy-27-noroleano-13(28)-lactone (1), (22α)-22-hydroxy-3-oxo-urs-12-ene-27,28-dioic acid (4), and (3β)-3-(β-D-glucopyranosyloxy)-12-oxopyroquinovic acid β-D-glucopyranosyl ester (7), together with four known compounds, pyrocincholic acid ethyl ester (2), pyrocincholic acid (3), quinovic acid (5), and (3β)-3-(β-D-quinovopyranosyloxy)pyrocincholic acid β-D-glucopyranosyl ester (6), were isolated from the EtOH extract of the leaves of Uncaria hirsutaHaviland. Their structures were determined by means of spectroscopic analyses, including HR-ESI-MS and 2D-NMR techniques. The configuration of 1 was confirmed by X-ray analysis; 2 is an artefact, as verified by the HPLC and LC/MS analysis.