DDT - a novel domain in different transcription and chromosome remodeling factors
DDT - a novel domain in different transcription and chromosome remodeling factors
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DOI：
10.1016/s0968-0004(00)01769-2
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发表时间：
2001-03-01
影响因子：
13.8
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Doerks, T;Copley, R;Bork, P
基于同源性的序列分析揭示了溴结构域 PHD 指转录因子 (BPTF)、BAZ 家族染色质重塑因子和其他假定的核蛋白中存在新结构域 (DDT)。该结构域的特征是许多保守的芳香族和带电残基，预计由三个 a 螺旋组成。最近的研究表明 DDT 结构域可能具有 DNA 结合功能。
Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three a helices. Recent studies indicate a likely DNA-binding function for the DDT domain.