COMPARISON OF PROGRESSIVE-RATIO PERFORMANCE MAINTAINED BY COCAINE, METHYLPHENIDATE AND SECOBARBITAL
COMPARISON OF PROGRESSIVE-RATIO PERFORMANCE MAINTAINED BY COCAINE, METHYLPHENIDATE AND SECOBARBITAL
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DOI：
10.1007/bf00437619
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
ROBINSON, WW
中科院分区：
文献类型：
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作者：
GRIFFITHS, RR;FINDLEY, JD;ROBINSON, WW
在药物维持递增比率程序中，比较了可卡因、哌醋甲酯和赛可巴比妥对狒狒受试者的影响。审判计划全天进行，在前一次审判结束后至少间隔3小时进行。在单次静脉输注药物终止的每一次试验中，“启动”杠杆上的比率反应要求是必需的。在低比率要求的累进比率程序中引入一种药物，以获得试验完成的高稳定频率的基线表现。比例要求每7天系统地增加一次，直到试验完成率降至标准水平以下时的“临界点”。受试者内部比较显示，在相同的绝对剂量，0.4毫克/公斤时，可卡因产生的断裂点高于哌醋甲酯。在所研究的剂量范围内，操纵剂量的哌甲酸甲酯(0.1-0.8 mg/kg)和可卡因(0.4-1.6 mg/kg)对断裂点影响不大。相比之下，增加剂量的赛可巴比妥(6.0和12.0毫克/公斤)会在相同的受试者中产生更高的转折点。
Cocaine, methylphenidate and secobarbital were compared on a drug maintained progressive-ratio procedure in baboon subjects. Trials, scheduled throughout the day, occurred at a minimum interval of 3 hrs after completion of the preceding trial. A ratio response requirement on the “initiate” lever was required during each trial which terminated in a single intravenous infusion of drug. A drug was introduced on the progressive-ratio procedure with a low ratio requirement in order to obtain a baseline performance of a high stable frequency of trial completion. The ratio requirement was systematically increased every 7 days until the “breaking point” when the rate of completing trials fell below a criterion level. Within-subject comparison revealed that cocaine produced higher breaking points than methylphenidate at the same absolute dose, 0.4 mg/kg. At the range of doses studied, manipulation of doses of methylphenidate (0.1–0.8 mg/kg) and cocaine (0.4–1.6 mg/kg) had little effect on breaking point. In contrast, increasing doses of secobarbital (6.0 and 12.0 mg/kg) produce higher breaking points within the same subjects.