A review of the global epidemiology of scrub typhus.
A review of the global epidemiology of scrub typhus.
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DOI：
10.1371/journal.pntd.0006062
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发表时间：
2017-11
影响因子：
3.8
通讯作者：
Arcari CM
中科院分区：
文献类型：
--
作者：
Xu G;Walker DH;Jupiter D;Melby PC;Arcari CM
斑疹伤寒是亚太地区严重的公共卫生问题。它威胁着全球10亿人，每年导致100万人患病。由恙虫病东方体引起的丛林斑疹伤寒可导致严重的多器官衰竭，如果不适当的治疗，病死率高达70%。钩端螺旋体的抗原性异质性排除了普通免疫，允许再次感染。作为一种被忽视的疾病，我们对这种疾病的认识仍然存在很大差距，关于斑疹伤寒流行地区的零星流行病学数据和其他相关公共卫生信息就是明证。我们的目标是对斑疹伤寒长期流行地区和最近发现的感染源的当前流行病学、预防和控制情况进行系统分析。斑疹伤寒是亚太地区严重的公共卫生问题。据估计，每年有100万新的丛林斑疹伤寒感染病例，世界各地有超过10亿人处于危险之中。如果治疗不当，森林斑疹伤寒的病死率可达30%甚至更高。森林斑疹伤寒长期以来一直是一种被忽视的传染病，因此该疾病的许多方面，包括其诊断和预防，都是未知的。我们在此对斑疹伤寒的流行病学、预防和控制进行全面综述。
Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas. Our objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection. Scrub typhus is a serious public health problem in the Asia-Pacific area. There is an estimated one million new scrub typhus infections each year, and over one billion people around the world are at risk. Without appropriate treatment, the case fatality rate of scrub typhus can reach 30% or even higher. Scrub typhus has long been a neglected infectious disease so many aspects of the disease, including its diagnosis to prevention, are unknown. We here provide a comprehensive review of the epidemiology, prevention and control of scrub typhus.
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影响因子：
--
作者：
BERGE, TO;GAULD, RL;KITAOKA, M
通讯作者：
KITAOKA, M
影响因子：
3.8
作者：
Bonell A;Lubell Y;Newton PN;Crump JA;Paris DH
通讯作者：
Paris DH
DOI：
10.4269/ajtmh.1973.22.796
发表时间：
1973-01-01
影响因子：
3.3
作者：
BERMAN, SJ;IRVING, GS;WATTEN, RH
通讯作者：
WATTEN, RH
影响因子：
1.5
作者：
Babu, Thirunavukkarasu Arun;Vijayadevagaran, Vijayasankar;Ananthakrishnan, Shanthi
通讯作者：
Ananthakrishnan, Shanthi
DOI：
10.1128/cvi.00553-15
发表时间：
2016-02
期刊：
Clinical and vaccine immunology : CVI
影响因子：
--
作者：
Blacksell SD;Tanganuchitcharnchai A;Nawtaisong P;Kantipong P;Laongnualpanich A;Day NP;Paris DH
通讯作者：
Paris DH