Hyaluronic acid: A key molecule in skin aging.
Hyaluronic acid: A key molecule in skin aging.
复制标题
DOI：
10.4161/derm.21923
复制
发表时间：
2012-07-01
期刊：
影响因子：
--
通讯作者：
Karakiulakis G
中科院分区：
文献类型：
--
作者：
Papakonstantinou E;Roth M;Karakiulakis G
皮肤老化是一个多因素过程，由两种不同且独立的机制组成：内在老化和外在老化。年轻的皮肤由于含水量高而保持其饱满度、弹性和柔韧度等。日常的外伤，除了正常的衰老过程之外，还会导致水分流失。参与皮肤保湿的关键分子是透明质酸 (HA)，它具有独特的保水能力。 HA的合成、沉积、细胞和蛋白质的结合和降解有多个位点控制，反映了HA代谢的复杂性。合成或分解HA的酶和负责HA的许多功能的HA受体都是具有不同组织表达模式的多基因家族。了解HA在皮肤不同层中的代谢以及HA与其他皮肤成分的相互作用将有助于以合理的方式调节皮肤水分。
Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.