Face-sensitive brain responses in the first year of life
Face-sensitive brain responses in the first year of life
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DOI：
10.1016/j.neuroimage.2020.116602
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发表时间：
2020-05-01
期刊：
影响因子：
5.7
通讯作者：
Roberts, Jane E.
中科院分区：
文献类型：
--
作者：
Conte, Stefania;Richards, John E.;Roberts, Jane E.
与非面孔刺激相比，腹侧视觉通路中的皮质区域从3个月左右开始选择性地调整为处理面孔，并持续到第一年。在EEG中使用事件相关电位(ERPs)的研究发现了一种ERP成分N290，它显示出对人脸的特异性。其他成分，如P1、P400和NC，在它们对人脸的反应方面已经被研究得较少。然而，关于婴儿出生一年期间对面孔的神经反应的系统性变化，以及这些反应在婴儿大脑中的定位，人们知之甚少。在一项横断面研究中，我们检查了4.5个月到12个月的婴儿对面孔和物体图片的事件相关电位反应。我们调查了所有被报道参与婴儿面部加工的成分的活性，特别是它们的幅度变化和皮质定位。我们通过应用皮层来源定位方法确定了负责该成分的神经区域。我们发现，P1和N290对面孔的反应比物体更大，这些成分分别定位于舌回和中/后梭形回。P400的波幅对物体上方的人脸不敏感。NC成分因人脸和物体不同而不同，受婴儿注意状态的影响，且定位于大脑内侧-前部区域。讨论了这些结果在识别面孔加工的发育事件相关电位前体方面的意义。
Cortical areas in the ventral visual pathway become selectively tuned towards the processing of faces compared to non-face stimuli beginning around 3 months of age and continuing over the first year. Studies using event-related potentials in the EEG (ERPs) have found an ERP component, the N290, that displays specificity for human faces. Other components, such as the P1, P400, and Nc have been studied to a lesser degree in their responsiveness to human faces. However, little is known about the systematic changes in the neural responses to faces during the first year of life, and the localization of these responses in infants' brain. We examined ERP responses to pictures of faces and objects in infants from 4.5 months through 12 months in a cross-sectional study. We investigated the activity of all the components reported to be involved in infant face processing, with particular interest to their amplitude variation and cortical localization. We identified neural regions responsible for the component through the application of cortical source localization methods. We found larger P1 and N290 responses to faces than objects, and these components were localized in the lingual and middle/posterior fusiform gyri, respectively. The amplitude of the P400 was not differentially sensitive to faces over objects. The Nc component was different for faces and objects, was influenced by the infant's attentional state, and localized in medial-anterior brain areas. The implications of these results are discussed in the identification of developmental ERP precursors to face processing.