Effect of tranilast in early-stage diabetic nephropathy
Effect of tranilast in early-stage diabetic nephropathy
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DOI：
10.1093/ndt/gfl325
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发表时间：
2006-10-01
影响因子：
6.1
通讯作者：
Tsuchiya, Yoshinori
中科院分区：
文献类型：
--
作者：
Soma, Jun;Sato, Kozo;Tsuchiya, Yoshinori
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Background. Tranilast is an antifibrotic drug known to suppress collagen synthesis by fibroblasts by interfering with the effects of TGF-beta. We recently reported that it slowed the progression rate of advanced diabetic nephropathy (DN) by reducing the accumulation of collagens in renal tissue. The present study was undertaken to examine the effect of tranilast on early-stage DN.Methods. Among out-patients with diabetes mellitus, we selected patients with (i) urinary albumin excretion of 30-1000 mg/g creatinine (/gCr) in the first morning urine, (ii) serum creatinine (SCr)