Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2CI
Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2CI
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DOI：
10.1021/ja805088r
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发表时间：
2008-10-01
影响因子：
15
通讯作者：
Ogoshi, Sensuke
中科院分区：
文献类型：
--
作者：
Nakao, Yoshiaki;Ebata, Shiro;Ogoshi, Sensuke
由镍和助催化剂AlMe 2Cl衍生的催化剂体系影响烯烃的分子内芳腈化。该反应以排他的exo-dig方式进行，以良好的产率得到广泛的具有苄基季碳的亚硝酸酯。详细调查的范围和机制，以及初步结果的不对称版本的反应，提供新的手性季立体中心。
A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitrites having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the asymmetric version of the reaction to provide novel access to chiral quaternary stereocenters.