Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
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DOI：
10.1038/ncb1721
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发表时间：
2008-05-01
影响因子：
21.3
通讯作者：
Jacobsen, Sten Eirik W.
中科院分区：
文献类型：
--
作者：
Nygren, Jens M.;Liuba, Karina;Jacobsen, Sten Eirik W.
最近的研究表明，非造血细胞谱系的再生可以通过异型细胞融合(1-3) 与骨髓谱系造血细胞(2 - 6) 进行。在这里，我们发现淋巴细胞还与心肌细胞、骨骼肌、肝细胞和浦肯野神经元形成异型融合杂交体。然而，通过谱系命运图谱，我们证明淋巴和骨髓血细胞的这种体内融合在稳态成体组织或正常发育过程中不会发生明显的程度。相反，血细胞与不同非造血细胞类型的融合是由器官特异性损伤或全身照射诱导的(1-10)，这在之前的研究中已被用于调节骨髓移植受者的状况。我们的研究结果表明，淋巴和骨髓谱系的血细胞通过形成罕见的融合杂种而对各种非造血组织做出贡献，但几乎完全是对损伤或炎症做出反应。
Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion(1-3) with haematopoietic cells of the myeloid lineage(2 - 6). Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation(1-10), which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.