Complement - tapping into new sites and effector systems
Complement - tapping into new sites and effector systems
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DOI：
10.1038/nri3761
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发表时间：
2014-12-01
影响因子：
100.3
通讯作者：
Kemper, Claudia
中科院分区：
文献类型：
--
作者：
Kolev, Martin;Le Friec, Gaelle;Kemper, Claudia
补体传统上被认为是一种血清蛋白系统，通过直接细胞裂解和动员先天性和适应性免疫来提供针对病原体的保护。然而，最近的研究表明，补体系统除了宿主防御之外还具有其他生理作用。在这篇评论文章中，我们描述了补体激活的新模式和位置，使其能够与其他细胞效应系统相互作用，例如生长因子受体、炎症小体和代谢途径。我们认为补体激活的位置决定了其功能。
Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.