Prevalence and Impact of Respiratory Viral Infections in Young Children With Cystic Fibrosis: Prospective Cohort Study
Prevalence and Impact of Respiratory Viral Infections in Young Children With Cystic Fibrosis: Prospective Cohort Study
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DOI：
10.1542/peds.2007-3139
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发表时间：
2008-12-01
期刊：
影响因子：
8
通讯作者：
van der Ent, Cornelis K.
中科院分区：
文献类型：
--
作者：
van Ewijk, Bart E.;van der Zalm, Marieke M.;van der Ent, Cornelis K.
目标。方法：在为期6个月的冬季期间，对20名囊性纤维症患儿和18名年龄匹配的健康对照儿童每周两次接触呼吸道病毒感染的症状，以检测急性呼吸道疾病的症状。如果出现任何症状，则进行家访，进行体检并收集鼻咽拭子进行病毒分析。此外，家长每2周采集一次鼻咽拭子。结果囊性纤维化症儿童和健康对照组儿童急性呼吸道疾病的发生率相似(分别为3.8+/-1.0和4.2+/-1.7次)。囊性纤维化组下呼吸道症状持续时间较长(22.4+/-22.2天比12.8±13.8天)，严重程度评分高(2.35+/-0.64天比1.92+/-0.46分)。此外，囊性纤维化儿童上呼吸道症状评分的类似增加与下呼吸道症状评分的显著增加有关。呼吸道病毒的季节性发生和分布没有差异，以微小核糖核酸病毒和冠状病毒最常见。结论：尽管聚合酶链式反应检测的呼吸道病毒的季节性发生和分布没有差异，但在囊性纤维化的幼儿中，急性呼吸道疾病经常与下呼吸道发病率增加有关。儿科2008；122：1171-1176
OBJECTIVE. We aimed to investigate differences in upper and lower respiratory tract symptoms in relation to respiratory viral infections detected with polymerase chain reaction assays in young children with cystic fibrosis and healthy control subjects.METHODS. In a 6-month winter period, 20 young children with cystic fibrosis and 18 age-matched, healthy, control subjects were contacted twice per week for detection of symptoms of an acute respiratory illness. If any symptom was present, then a home visit was made for physical examination and collection of nasopharyngeal swabs for viral analysis. In addition, parents were instructed to collect nasopharyngeal swabs every 2 weeks.RESULTS. Children with cystic fibrosis and healthy control subjects had similar frequencies of acute respiratory illnesses (3.8 +/- 1.0 and 4.2 +/- 1.7 episodes, respectively). Although there were no significant differences in upper respiratory tract symptoms, the children with cystic fibrosis had longer periods of lower respiratory tract symptoms (22.4 +/- 22.2 vs 12.8 +/- 13.8 days) and a higher mean severity score per episode (2.35 +/- 0.64 vs 1.92 +/- 0.46). In addition, similar increases in upper respiratory tract symptom scores were associated with significantly greater increases in lower respiratory tract symptom scores in children with cystic fibrosis. No differences in the seasonal occurrences and distributions of respiratory viruses were observed, with picornaviruses and coronaviruses being the most prevalent.CONCLUSIONS. Although there were no differences in the seasonal occurrences and distributions of polymerase chain reaction-detected respiratory viruses, acute respiratory illnesses were frequently associated with increased lower respiratory tract morbidity in young children with cystic fibrosis. Pediatrics 2008; 122: 1171-1176