DIFFERENTIAL EXPRESSION OF MITOCHONDRIAL GENES BETWEEN LIFE-CYCLE STAGES OF TRYPANOSOMA-BRUCEI
DIFFERENTIAL EXPRESSION OF MITOCHONDRIAL GENES BETWEEN LIFE-CYCLE STAGES OF TRYPANOSOMA-BRUCEI
复制标题
DOI：
10.1073/pnas.82.10.3380
复制
发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
STUART, K
中科院分区：
文献类型：
--
作者：
FEAGIN, JE;STUART, K
线粒体呼吸系统在寄生原生动物T.布鲁塞。转录物（14）来源于含有与细胞色素c氧化酶亚基I和II同源的序列的大环（线粒体DNA）区域，来自其他生物体的线粒体DNA的未分配阅读框1，和2个其他开放阅读框。这些转录本中有10个是成对出现的，大小相差. apprx。200个核苷酸。虽然这些转录本中的大多数在两种生命周期形式中发生，但4种转录本差异表达。其中，2种在血流形式中更丰富，1种在前循环形式中更丰富，1种存在于前循环但不是血流形式中。线粒体呼吸系统的差异生产在T。布氏杆菌显然需要线粒体转录和/或转录后过程的调节。
The mitochondrial respiratory system is differentially produced during the life cycle of the parasitic protozoan, T. brucei. Transcripts (14) that are derived from a maxicircle (mitochondrial DNA) region that contains sequences homologous to cytochrome c oxidase subunits I and II, unassigned reading frame 1 from mitochondrial DNA of other organisms, and 2 other open reading frames. Ten of these transcripts occur as pairs that differ in size by .apprx. 200 nucleotides. While most of these transcripts occur in both life cycle forms, 4 transcripts are differentially expressed. Of these, 2 are more abundant in bloodstream forms, 1 is more abundant in procyclic forms, and 1 is present in procyclic but not bloodstream forms. The differential production of the mitochondrial respiratory system in T. brucei apparently entails regulation of mitochondrial transcriptional and/or posttranscriptional processes.