Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study.
Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study.
复制标题
贪食症患者前额皮质的血流动力学反应和人格特征：近红外光谱研究。
DOI：
10.1007/s40519-018-0500-7
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Nakazato M.
中科院分区：
文献类型：
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作者：
Numata N;Hirano Y;Sutoh C;Matsuzawa D;Takeda K;Setsu R;Shimizu E;Nakazato M.
PurposeThis study seemed to identify the prefrontal cortex bloodflow response that is dependent on cognitive performance in patients with bulimic disorders（BD），and investigate its association with personality characteristics. Methods19 female patients with BD and 23 healthy women were recruited.他们的人格特征相关的饮食失调进行了检查，使用自我报告问卷，即饮食失调量表-2（EDI-2）。采用近红外光谱技术（NIRS）测量了数字背越任务（DSBT）时前额叶皮层的脑血流反应。用近红外光谱（NIRS）测定氧合血红蛋白浓度（ΔoxyHb）的变化，作为脑活动的指标。此外，前额叶皮层活动和人格特征之间的关系进行了研究，在BD患者。结果BD患者的认知性能显着低于DSBT与健康人相比。在任务期间，两组之间的ΔoxyHb没有差异。BD患者的任务得分与禁欲主义和完美主义相关。BD患者的禁欲行为评分与双侧前额叶皮质的ΔoxyHb呈负相关。结论BD患者的禁欲行为可能影响DSBT时的认知能力和脑活动。
PurposeThis study sought to identify the prefrontal cortex hemodynamic response that is dependent on cognitive performance in patients with bulimic disorders (BD), and investigate its association with personality characteristics.MethodsNineteen female patients with BD and 23 healthy women were recruited. Their personality characteristics related to eating disorders were examined using a self-reporting questionnaire, namely the eating disorder inventory-2 (EDI-2). Cerebral blood flow response in the prefrontal cortex during the digit span backward task (DSBT) was measured using near-infrared spectroscopy (NIRS). Change in oxygenated hemoglobin concentration (ΔoxyHb), obtained using NIRS, were used as an index of brain activity. Further, the relationship between prefrontal cortical activity and personality characteristics was investigated in patients with BD.ResultsThe cognitive performance of patients with BD was significantly lower in the DSBT compared with healthy subjects. There was no difference between the groups in ΔoxyHb during the task. Task scores of patients with BD correlated with asceticism and perfectionism. Moreover, the asceticism score was negatively correlated with ΔoxyHb of the bilateral prefrontal cortex in patients with BD.ConclusionThe results suggest that cognitive performance and brain activity induced during DSBT might be affected by asceticism in BD patients.Level of evidenceIII, case-control study.