Time course of visuospatial neglect early after stroke: A longitudinal cohort study
Time course of visuospatial neglect early after stroke: A longitudinal cohort study
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DOI：
10.1016/j.cortex.2012.11.006
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发表时间：
2013-09-01
期刊：
影响因子：
3.6
通讯作者：
Kwakkel, Gert
中科院分区：
文献类型：
--
作者：
Nijboer, Tanja C. W.;Kollen, Boudewijn J.;Kwakkel, Gert
本研究的目的是调查中风后第一年内视觉空间忽略的恢复情况。视觉空间忽略的测量使用两个经常和广泛使用的测试：字母取消测试（LCT）和线平分测试（LBT）。这是一项纳入101例卒中患者的前瞻性队列研究。在这101例患者中，51例患者表现出视觉空间忽视。从卒中发作后14天内开始，每周进行一次所有时间依赖性测量。从第10-20周，每两周进行一次测量。在第26、38和最后52周进行随访测量。对于本研究，使用了LCT中的缺失数量、对侧病灶与同侧病灶的分割以及LBT中与实际中点的偏差（mm）。采用随机系数分析和联合点分析方法，对LBT和LCT改善（双）周时间的纵向关系进行了研究。结果表明，时间的进展是一个独立的协变量，反映神经恢复的视觉空间忽视。此外，在卒中后12至14周期间，就被忽略的一侧而言，获得了趋势变化。这是第一个前瞻性队列研究，其中忽视的时间进程进行了调查，在中风后的最初几个月使用密集的系列测量。(c)2012爱思唯尔有限公司保留所有权利。
The aim of the current study was to investigate recovery of visuospatial neglect during the first year after stroke. Visuospatial neglect was measured using two frequently and widely used tests: the letter cancellation test (LCT) and the line bisection test (LBT). This was a prospective cohort study of 101 stroke patients. Of these 101 patients, 51 patients showed visuospatial neglect. All time-dependent measures were taken weekly, starting from within 14 days after stroke onset. From week 10-20 biweekly measurements were obtained. Follow-up measurements were performed at weeks 26, 38, and finally 52. For the present study, number of misses in the LCT, split on contralesional versus ipsilesional side, as well as the deviation from the actual midpoint in mm in the LBT were used. The longitudinal relationship of (bi)weekly time on improvement in LBT and LCT were investigated using random coefficient analysis and joinpoint analyses. Results indicated that progress of time is an independent covariate that reflects neurological recovery of visuospatial neglect. Additionally, trend changes were obtained in between 12 and 14 weeks post-stroke with respect to the neglected side. This is the first prospective cohort study in which the time course of neglect is investigated by using intensive serial measurements in the early months post-stroke. (c) 2012 Elsevier Ltd. All rights reserved.