SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera.
SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera.
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DOI：
10.1016/j.isci.2021.103467
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发表时间：
2021-12-17
期刊：
影响因子：
5.8
通讯作者：
Taube R
中科院分区：
文献类型：
--
作者：
Kuzmina A;Wattad S;Khalaila Y;Ottolenghi A;Rosental B;Engel S;Rosenberg E;Taube R
自从被发现以来，严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）Kappa和Delta迅速蔓延，成为全球主导。然而，它们的传染性和对接种疫苗的敏感性还没有记录。我们监测了恢复期或BNT 162 b2疫苗接种后血清对Kappa和Delta SARS-CoV-2假病毒的中和潜力。我们表明，这两种变体被成功地中和恢复期和接种后血清，表现出温和的减少，其中和敏感性。在这两种变体中，Delta与Kappa或野生型SARS-CoV-2相比呈现出增强的感染性水平。然而，两种变体的感染性或对疫苗接种后血清的耐药性均不如关注的β变体。有趣的是，Delta plus变异体（AY.1/B.1.617.2.1）对接种后血清表现出高抗性，与β SARS-CoV-2相似。然而，其感染性水平接近野生型SARS-CoV-2。这些结果说明了Delta变异体的全球流行率，并证实了BNT 162 b2疫苗对其他流行Delta变异体的有效性。Pfizer疫苗有效中和Kappa和Delta SARS-CoV-2变异体Delta变异体相对于野生型SARS-CoV-2 Beta表现出高感染性水平，Delta plus变异体表现出对疫苗的中和抗性增加
Since their identification, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Kappa and Delta have rapidly spread to become globally dominant. However, their infectivity and sensitivity to administered vaccines have not been documented. We monitored the neutralization potential of convalescent or BNT162b2 post-vaccination sera against Kappa and Delta SARS-CoV-2 pseudoviruses. We show that both variants were successfully neutralized by convalescent and post-vaccination sera, exhibiting a mild decrease in their neutralization sensitivity. Of the two variants, Delta presented enhanced infectivity levels compared with Kappa or wild-type SARS-CoV-2. Nevertheless, both variants were not as infectious or resistant to post-vaccination sera as the Beta variant of concern. Interestingly, the Delta plus variant (AY.1/B.1.617.2.1) exhibited high resistance to post-vaccination sera, similar to that of the Beta SARS-CoV-2. However, its infectivity levels were close to those of wild-type SARS-CoV-2. These results account for the worldwide prevalence of Delta variant of concern and confirm the efficacy of the BNT162b2 vaccine against circulating other Delta variants. Pfizer vaccine efficiently neutralizes Kappa and Delta SARS-CoV-2 variants The Delta variant exhibits high infectivity levels relative to wild-type SARS-CoV-2 Beta and Delta plus variants exhibit increased neutralization resistance to vaccine Immunology; Virology
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
DOI：
10.1126/science.abe8499
发表时间：
2020-12-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hou YJ;Chiba S;Halfmann P;Ehre C;Kuroda M;Dinnon KH 3rd;Leist SR;Schäfer A;Nakajima N;Takahashi K;Lee RE;Mascenik TM;Graham R;Edwards CE;Tse LV;Okuda K;Markmann AJ;Bartelt L;de Silva A;Margolis DM;Boucher RC;Randell SH;Suzuki T;Gralinski LE;Kawaoka Y;Baric RS
通讯作者：
Baric RS
DOI：
10.4049/jimmunol.2000583
发表时间：
2020-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Alsoussi WB;Turner JS;Case JB;Zhao H;Schmitz AJ;Zhou JQ;Chen RE;Lei T;Rizk AA;McIntire KM;Winkler ES;Fox JM;Kafai NM;Thackray LB;Hassan AO;Amanat F;Krammer F;Watson CT;Kleinstein SH;Fremont DH;Diamond MS;Ellebedy AH
通讯作者：
Ellebedy AH
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1016/j.ijid.2020.11.128
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Giandhari J;Pillay S;Wilkinson E;Tegally H;Sinayskiy I;Schuld M;Lourenço J;Chimukangara B;Lessells R;Moosa Y;Gazy I;Fish M;Singh L;Sedwell Khanyile K;Fonseca V;Giovanetti M;Carlos Junior Alcantara L;Petruccione F;de Oliveira T
通讯作者：
de Oliveira T