Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage
Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage
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入院中性粒细胞计数和中性粒细胞与淋巴细胞比率可预测脑出血的 90 天结果
DOI：
10.2217/bmm-2016-0187
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发表时间：
2017-01-01
影响因子：
2.2
通讯作者：
You, Chao
中科院分区：
文献类型：
--
作者：
Tao, Chuanyuan;Hu, Xin;You, Chao
目的：炎症反应在脑出血后继发性脑损伤中起重要作用。我们的目的是确定入院白色血细胞（AWC）、中性粒细胞计数（ANC）、淋巴细胞计数、单核细胞计数和中性粒细胞与淋巴细胞比率（NLR）对ICH后90天预后的意义。患者与方法：对336例自发性脑出血患者进行回顾性研究。90天时采用改良兰金量表评价临床结局。结果：多因素分析显示，较高的AWC、ANC、NLR与死亡率和不良预后独立相关。此外，在受试者操作特征分析中，NLR对死亡率的预测能力高于对不良结局的预测能力。线性回归分析显示，入院时格拉斯哥昏迷评分和脑出血体积与这些指标相关性最大。结论：AWC、ANC和NLR水平升高与ICH后90天预后不良独立相关。NLR可能是脑出血后一种新的炎症生物标志物。
Aim: Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH. Patients & methods: A total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days. Results: Multivariate analysis showed that higher AWC, ANC, NLR were independently associated with mortality and worse outcome. Moreover, NLR showed a higher predictive ability in mortality than in poor outcome in receiver operating characteristic analysis. Linear regression analyses revealed admission Glasgow Coma Scale score and ICH volume were mostly correlated with these indices. Conclusion: Elevated levels of AWC, ANC and NLR were independently related to poor 90-day outcome after ICH. NLR may be a novel inflammatory biomarker following ICH.