The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time.
The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time.
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DOI：
10.1098/rstb.2014.0297
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发表时间：
2015-08-19
期刊：
影响因子：
--
通讯作者：
Parr N
中科院分区：
文献类型：
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作者：
Koskella B;Parr N
洞察共同进化的空间和时间尺度是预测宿主-寄生虫相互作用和疾病传播结果的关键。对于感染长寿宿主的细菌来说，克服宿主防御的选择只是影响进化过程的因素之一；种群还将与其他微生物物种竞争，自己将面临噬菌体病毒的感染。在这里，我们研究了细菌对板栗树叶片内天然噬菌体种群的适应的时间和空间模式。使用来自当代或本季节早期时间点的共域和异地噬菌体的时移实验，我们证明了细菌对过去的噬菌体的抵抗力更高，无论空间同源性或本季节早些时候收集了多少噬菌体。同样，我们表明未来的细菌宿主比当代的细菌宿主对共域和异地噬菌体都更具抵抗力。综上所述，我们的结果表明，自然界中细菌对噬菌体的抗性是相对普遍的，并且与之前观察到的噬菌体对同一树宿主细菌在同一时间框架内的适应模式形成了对比，表明共同进化动力学中可能存在不对称。
Insight to the spatial and temporal scales of coevolution is key to predicting the outcome of host–parasite interactions and spread of disease. For bacteria infecting long-lived hosts, selection to overcome host defences is just one factor shaping the course of evolution; populations will also be competing with other microbial species and will themselves be facing infection by bacteriophage viruses. Here, we examine the temporal and spatial patterns of bacterial adaptation against natural phage populations from within leaves of horse chestnut trees. Using a time-shift experiment with both sympatric and allopatric phages from either contemporary or earlier points in the season, we demonstrate that bacterial resistance is higher against phages from the past, regardless of spatial sympatry or how much earlier in the season phages were collected. Similarly, we show that future bacterial hosts are more resistant to both sympatric and allopatric phages than contemporary bacterial hosts. Together, our results suggest the evolution of relatively general bacterial resistance against phages in nature and are contrasting to previously observed patterns of phage adaptation to bacteria from the same tree hosts over the same time frame, indicating a potential asymmetry in coevolutionary dynamics.