Thermosensitive biodegradable polydepsipeptide.
Thermosensitive biodegradable polydepsipeptide.
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DOI：
10.1002/mabi.200400221
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发表时间：
2005-04
影响因子：
4.6
通讯作者：
Y. Ohya;M. Toyohara;M. Sasakawa;Hidetoshi Arimura;T. Ouchi
中科院分区：
文献类型：
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作者：
Y. Ohya;M. Toyohara;M. Sasakawa;Hidetoshi Arimura;T. Ouchi
通过在聚[Glc-Asn]中引入异丙基酰胺基团，合成了一种类聚（N-异丙基丙烯酰胺）（PNIPAAm）的可生物降解温敏聚缩酚酸肽聚[Glc-Asn（N-异丙基）]。聚[Glc-Asn（N-异丙基）]在室温下通过在水中裂解主链中的酯键而在体外降解。聚合物及其降解产物的无毒性质，加上在水中的浊点为29 ℃，使这种聚合物对生物医学植入应用具有吸引力。
A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications.