A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
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DOI：
10.1056/nejm199908263410904
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发表时间：
1999-08-26
影响因子：
158.5
通讯作者：
Hennekens, CH
中科院分区：
文献类型：
--
作者：
Manson, JE;Hu, FB;Hennekens, CH
背景 与剧烈运动相比，步行在预防冠心病方面的作用仍存在争议，并且关于这一主题的女性数据很少。方法我们前瞻性地研究了 1986 年 72,488 名 40 至 65 岁女护士的总体体力活动、步行和剧烈运动得分与冠状动脉事件发生率之间的关联。参与者在进入和进入时均未诊断出患有心血管疾病或癌症。 完成有关身体活动的系列详细调查问卷。在八年的随访期间，我们记录了 645 起冠状动脉事件（非致命性心肌梗塞或冠状动脉疾病死亡）。结果 体力活动与冠状动脉事件风险之间存在强烈的分级负相关关系。与能量消耗最低的五分位组中的女性（以代谢当量 [MET] 评分表示）相比，增加五分位组中的女性的冠状动脉事件的年龄调整相对风险分别为 0.77、0.65、0.54 和 0.46（P 为趋势）
Background The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse.Methods We prospectively examined the associations between the score for total physical activity, walking, and vigorous exercise and the incidence of coronary events among 72,488 female nurses who were 40 to 65 years old in 1986. Participants were free of diagnosed cardiovascular disease or cancer at the time of entry and completed serial detailed questionnaires about physical activity. During eight years of follow-up, we documented 645 incident coronary events (nonfatal myocardial infarction or death from coronary disease).Results There was a strong, graded inverse association between physical activity and the risk of coronary events. As compared with women in the lowest quintile group for energy expenditure (expressed as the metabolic-equivalent [MET] score), women in increasing quintile groups had age-adjusted relative risks of 0.77 0.65, 0.54, and 0.46 for coronary events (P for trend