Continuum-kinetic-microscopic model of lung clearance due to core-annular fluid entrainment.
Continuum-kinetic-microscopic model of lung clearance due to core-annular fluid entrainment.
复制标题
由于核心-环形液体夹带而产生的肺间隙的连续动力学微观模型。
DOI：
10.1016/j.jcp.2013.01.037
复制
发表时间：
2013
影响因子：
4.1
通讯作者：
Mitran,Sorin
中科院分区：
文献类型：
--
作者：
Mitran,Sorin
人的肺通过衬在气道内部的薄液体层来保护免受吸入的传染性和有毒物质的侵害。该气道表面液体是由粘弹性粘液层组成的双层，该粘弹性粘液层由称为纤毛周围液体的流体膜支撑。粘液层的粘弹性行为主要是由于称为粘蛋白的长链聚合物。气道表面液体通过纤毛运输、表面张力梯度和气流剪切力从肺中清除。这项工作提出了一个多尺度模型的气流剪切力的影响，所施加的潮汐呼吸和咳嗽，清除后。粘液层的组成是复杂的，并随时间变化。为了避免通过采用有限有效性的粘弹性流动模型所施加的限制，引入了多尺度计算模型，其中气道表面液体的连续水平特性由长链聚合物的微观模拟来确定。通过描述聚合物链构型的动力学水平概率密度函数，在微观和连续水平之间搭建了一座桥梁。整体多尺度框架是特别适合于生物学问题，由于提供的灵活性，在指定微观成分，并检查各种成分的影响后，整体粘液运输在连续尺度。
The human lung is protected against aspirated infectious and toxic agents by a thin liquid layer lining the interior of the airways. This airway surface liquid is a bilayer composed of a viscoelastic mucus layer supported by a fluid film known as the periciliary liquid. The viscoelastic behavior of the mucus layer is principally due to long-chain polymers known as mucins. The airway surface liquid is cleared from the lung by ciliary transport, surface tension gradients, and airflow shear forces. This work presents a multiscale model of the effect of airflow shear forces, as exerted by tidal breathing and cough, upon clearance. The composition of the mucus layer is complex and variable in time. To avoid the restrictions imposed by adopting a viscoelastic flow model of limited validity, a multiscale computational model is introduced in which the continuum-level properties of the airway surface liquid are determined by microscopic simulation of long-chain polymers. A bridge between microscopic and continuum levels is constructed through a kinetic-level probability density function describing polymer chain configurations. The overall multiscale framework is especially suited to biological problems due to the flexibility afforded in specifying microscopic constituents, and examining the effects of various constituents upon overall mucus transport at the continuum scale.