The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults
The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults
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DOI：
10.1159/000487677
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发表时间：
2018-03
影响因子：
2.8
通讯作者：
Jiawen Hu;Yang Wang;C. Chu;Yu Yan;Ke-ke Wang;Wen-ling Zheng;Qiong Ma;Y. Lv;Yin-quan Deng;Bo Yan;J. Mu
中科院分区：
文献类型：
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作者：
Jiawen Hu;Yang Wang;C. Chu;Yu Yan;Ke-ke Wang;Wen-ling Zheng;Qiong Ma;Y. Lv;Yin-quan Deng;Bo Yan;J. Mu
背景/目标：在不同人群中，血尿酸（UA）升高与血管僵硬度和踝臂指数（ABI）异常密切相关。在校正估计的肾小球滤过率（eGFR）后，这些相关性失去了意义，表明UA和臂踝脉搏波速度（baPWV）或ABI的相关性可能是由肾功能驱动的。UA主要通过肾脏消除，代谢紊乱可影响UA的清除。在这项研究中，我们的目的是探讨FEUA和baPWV或ABI之间的假定相关性，以确定在何种程度上与UA的相关性受到肾功能的影响。研究方法：本横断面研究纳入了2351名参与者，他们于2017年3月至6月在汉中市人民医院接受了一般健康筛查。BaPWV和ABI使用体积描记仪（BP-203 RPEII; Nihon Colin，Tokyo，Japan）测量。FEUA分为四分位数：Q1：FEUA≤3.07; Q2：3.07 9.19。结果：FEUA越低，baPWV越高，ABI越低（p <0.001）。FEUA第一至第三四分位数的高baPWV的OR分别为1.777（1.323，2.387）; 1.561（1.158，2.104）;和1.680（1.250，2.259）。低ABI的患病率随着FEUA的降低而显著升高[FEUA第一至第三四分位数的OR分别为6.977（2.062，23.610）; 5.123（1.475，17.790）;和2.685（0.709，10.171）]。FEUA和ABI的相关性独立于相关混杂因素。然而，FEUA和baPWV之间的关联受到相应混杂因素的影响，特别是性别。FEUA对低ABI的预测作用强于血清UA。然而，血清UA在预测高baPWV方面更有效。结论：肾功能对UA和baPWV或ABI之间的关系产生了深远的影响，揭示了心血管危险因素之间复杂的相互作用。
Background/Aims: Elevated serum uric acid (UA) was intimately correlated with vascular stiffness and abnormal ankle brachial index (ABI) in various populations. These correlations lost significance after adjustment for estimated glomerular filtration rate (eGFR), indicating that the association of UA and brachial-ankle pulse wave velocity (baPWV) or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA. In this study, we aimed to explore the putative correlation between FEUA and baPWV or ABI to determine to what extent the associations with UA were affected by renal function. Methods: This cross-sectional study enrolled 2351 participants, who underwent general health screening in Hanzhong people’s hospital from March to June of 2017. BaPWV and ABI were measured using a volume-plethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan). FEUA was divided into quartiles: Q1:FEUA≤3.07; Q2: 3.07 9.19. Results: Lower FEUA predicted a higher prevalence of high baPWV and low ABI (p for trend <0.001). The respective ORs for high baPWV from the first to the third quartiles of FEUA were 1.777(1.323, 2.387); 1.561(1.158, 2.104); and 1.680 (1.250, 2.259). The prevalence of low ABI was greatly elevated with the decrement of FEUA [ORs for the first to third FEUA quartiles were 6.977(2.062, 23.610); 5.123(1.475, 17.790); and 2.685(0.709, 10.171), respectively]. The association of FEUA and ABI was independent of related confounding factors. However, the association between FEUA and baPWV was greatly influenced by corresponding confounders, especially gender. The efficacy of FEUA in the prediction of low ABI was stronger than that of serum UA. However, serum UA was more powerful in the prediction of high baPWV. Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors.