NATURAL HISTORY OF CONGESTIVE HEART FAILURE - FRAMINGHAM STUDY
NATURAL HISTORY OF CONGESTIVE HEART FAILURE - FRAMINGHAM STUDY
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DOI：
10.1056/nejm197112232852601
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发表时间：
1971-01-01
影响因子：
158.5
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
--
作者：
MCKEE, PA;CASTELLI, WP;KANNEL, WB
对5192名最初无充血性心力衰竭的患者进行了为期16年的充血性心力衰竭自然史研究。在此期间，142人出现明显的充血性心力衰竭迹象。在30至62岁的几乎每一个5岁年龄组中，男性的发病率都高于女性。虽然发现了常见的病因前兆，但占主导地位的明显是高血压，75%的病例在失败之前。39%的人在早期检查时发现有冠心病，但29%的人伴有高血压。在21%的充血性心力衰竭病例中发现了复发性风湿性心脏病，11%伴有高血压，尽管有现代治疗，充血性心力衰竭被证明是极其致命的。在充血性心力衰竭发病后五年内死亡的概率，男性为62%，女性为42%。
The natural history of congestive heart failure was studied over a 16-year period in 5192 persons initially free of the disease. Over this period, overt evidence of congestive heart failure developed in 142 persons. In almost every five-year age group, from 30 to 62 years, the incidence rate was greater for men than for women. Although the usual etiologic precursors were found, the dominant one was clearly hypertension, which preceded failure in 75 per cent of the cases. Coronary heart disease was noted at an earlier examination in 39 per cent, but in 29 per cent of the cases it was accompanied by hypertension. Precursive rheumatic heart disease, noted in 21 per cent of cases of congestive heart failure, was accompanied by hypertension in 11 per cent. Despite modern management, congestive heart failure proved to be extremely lethal. The probability of dying within five years from onset of congestive heart failure was 62 per cent for men and 42 per cent for women.