pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans
pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans
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DOI：
10.1101/gad.12.13.1947
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发表时间：
1998-07-01
影响因子：
10.5
通讯作者：
Mango, SE
中科院分区：
文献类型：
--
作者：
Horner, MA;Quintin, S;Mango, SE
为了构建复杂的器官，胚胎已经进化出了整合细胞类型或祖先彼此无关的细胞发育的机制。在这里，我们表明，PHA-4基因座建立器官识别秀丽隐杆线虫咽。在pha-4突变体中，咽细胞转化为外胚层。相反，异位的pha-4表达产生过量的咽细胞，pha-4编码HNF-3同源物，其选择性地在新生消化道中表达，包括所有咽前体在它们被限制于咽命运时。我们认为，PHA-4是一个关键组成部分的转录为基础的机制，赋予细胞与咽器官的身份。
To build complex organs, embryos have evolved mechanisms that integrate the development of cells unrelated to one another by cell type or ancestry. Here we show that the pha-4 locus establishes organ identity for the Caenorhabditis elegans pharynx. In pha-4 mutants, pharyngeal cells are transformed into ectoderm. Conversely, ectopic pha-4 expression produces excess pharyngeal cells, pha-4 encodes an HNF-3 homolog selectively expressed in the nascent digestive tract, including all pharynx precursors at the time they are restricted to a pharyngeal fate. We suggest that pha-4 is a key component of a transcription-based mechanism to endow cells with pharyngeal organ identity.