Quantitative imaging of 124I and 86Y with PET.
Quantitative imaging of 124I and 86Y with PET.
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DOI：
10.1007/s00259-011-1768-2
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发表时间：
2011-05
影响因子：
9.1
通讯作者：
Herzog, Hans
中科院分区：
文献类型：
--
作者：
Lubberink, Mark;Herzog, Hans
使用124 I和86 Y的正电子发射断层扫描（PET）测量的定量准确性和图像质量受到伽马辐射和正电子在其衰变中的即时发射以及与18 F发射的正电子相比发射的正电子的更高能量的影响。如果瞬发伽马的能量在扫描仪的能量窗口内，PET扫描仪无法区分涉及两个511-keV湮灭光子的真实符合和涉及一个湮灭光子和瞬发伽马的符合。目前的审查涉及的一些方面的挑战，这对定量PET成像。首先，即时伽玛符合PET图像的定量准确性的影响进行了讨论，并提出了一些建议的校正。然后，提示伽玛符合和增加的单计数率由于伽玛辐射对PET的计数率性能的影响被解决，以及可能的改进的基础上修改扫描仪的能量窗口。最后，评估了正电子能量对空间分辨率和恢复的影响。本概述中介绍的方法旨在克服与124 I和86 Y衰变特性相关的挑战。所提出的校正方法的仔细应用可以允许具有改进的图像对比度的定量准确的图像。
The quantitative accuracy and image quality of positron emission tomography (PET) measurements with 124I and 86Y is affected by the prompt emission of gamma radiation and positrons in their decays, as well as the higher energy of the emitted positrons compared to those emitted by 18F. PET scanners cannot distinguish between true coincidences, involving two 511-keV annihilation photons, and coincidences involving one annihilation photon and a prompt gamma, if the energy of this prompt gamma is within the energy window of the scanner. The current review deals with a number of aspects of the challenge this poses for quantitative PET imaging. First, the effect of prompt gamma coincidences on quantitative accuracy of PET images is discussed and a number of suggested corrections are described. Then, the effect of prompt gamma coincidences and the increased singles count rates due to gamma radiation on the count rate performance of PET is addressed, as well as possible improvements based on modification of the scanner’s energy windows. Finally, the effect of positron energy on spatial resolution and recovery is assessed. The methods presented in this overview aim to overcome the challenges associated with the decay characteristics of 124I and 86Y. Careful application of the presented correction methods can allow for quantitatively accurate images with improved image contrast.
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