Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan
Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan
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DOI：
10.1016/j.jep.2008.01.018
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发表时间：
2008-04-17
影响因子：
5.4
通讯作者：
Hwang, Shinn-Jang
中科院分区：
文献类型：
--
作者：
Chen, Fang-Pey;Kung, Yen-Ying;Hwang, Shinn-Jang
民族药理学相关性：研究目的：进行一项大规模的药物流行病学研究，并评估中药处方治疗慢性肝炎的频率和模式。材料和方法：我们获得了2002年台湾全民健康保险的中医门诊索赔数据库。根据国际疾病分类的相应诊断，在申报的就诊档案中确定慢性肝炎患者。结果：91 080例慢性肝炎患者中，以40岁为用药高峰，其次为30岁和50岁。男女比例为2.07：1。龙胆泻肝汤和丹参分别是最常用的中药处方和单味中药。最常见的二药方为加味下腰散加丹参，最常见的三药方为加味下腰散加丹参、茵陈。结论：本研究揭示了治疗慢性肝炎的中草药或方剂的使用规律。这些中药或其成分治疗慢性肝炎的疗效有待于进一步的研究和临床试验。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Ethnopharmacological relevance: Chinese herbal medicine (CHM) has been commonly used in treating liver diseases in Asian countries.Aim of study: To conduct a large-scale pharmacoepidemiological study and evaluate the frequency and pattern of CHM prescriptions in treating chronic hepatitis.Materials and methods: We obtained the database of traditional Chinese medicine outpatient claims from the national health insurance in Taiwan for the whole 2002. Patients with chronic hepatitis were identified by the corresponding diagnosis of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and association rule were applied to evaluate the co-prescription of CHM in treating chronic hepatitis.Results: Among the 91,080 subjects treated by CHM for chronic hepatitis, the peak age was in the 40s, followed by 30s and 50s. Male/female ratio was 2.07:1. Long-dan-xie-gan-tang and Saliva miltiorrhiza (Dan-shen) were the most commonly prescribed Chinese herbal formula and single herbal drug, respectively. The most common two-drug prescription was Jia-wei-xia-yao-san plus Saliva miltiorrhiza, and the most common three-drug prescription was Jia-wei-xia-yao-san plus Saliva miltiorrhiza and Artemisia capillaries (Yin-chen-hao).Conclusions: This study showed the utilization pattern of Chinese herbal drugs or formulae in treating chronic hepatitis. Further researches and clinical trials are needed to evaluate the efficacy of these Chinese herbs or its ingredients in treating chronic hepatitis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.