Concurrent measurement of cerebral hemodynamics and electroencephalography during transcranial direct current stimulation.
Concurrent measurement of cerebral hemodynamics and electroencephalography during transcranial direct current stimulation.
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在经颅直流电流刺激过程中，同时测量脑血液动力学和脑电图。
DOI：
10.1117/1.nph.5.1.015001
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发表时间：
2018-01
期刊：
影响因子：
5.3
通讯作者：
Durduran T
中科院分区：
文献类型：
--
作者：
Giovannella M;Ibañez D;Gregori-Pla C;Kacprzak M;Mitjà G;Ruffini G;Durduran T
经颅直流电刺激目前被用于一些神经和神经精神疾病的研究和治疗，以及认知功能的改善。为了更好地了解大脑对刺激的反应，并重新定义方案和剂量，必须监测其效果。为此，我们使用了功能扩散相关光谱(FDCS)和时间分辨功能近红外光谱(tr-fNIRS)结合脑电(EEG)在刺激额叶皮质的过程中和之后。20名受试者参加了用两种不同极性蒙太奇进行的两次刺激，12名受试者也接受了假刺激。刺激电极下方区域在刺激过程中和刺激后，脑血流量和氧合血红蛋白浓度增加，脱氧血红蛋白浓度降低。脑电频谱在不同的刺激过程中显示出统计上显著的功率变化，在增量(2到4赫兹)、β(4到8赫兹)和贝塔(12到18赫兹)频段。结果表明，FDDC和tr-fNIRS可作为经颅电刺激效应的神经监测仪，并可与EEG联合使用。
Transcranial direct current stimulation (tDCS) is currently being used for research and treatment of some neurological and neuropsychiatric disorders, as well as for improvement of cognitive functions. In order to better understand cerebral response to the stimulation and to redefine protocols and dosage, its effects must be monitored. To this end, we have used functional diffuse correlation spectroscopy (fDCS) and time-resolved functional near-infrared spectroscopy (TR-fNIRS) together with electroencephalography (EEG) during and after stimulation of the frontal cortex. Twenty subjects participated in two sessions of stimulation with two different polarity montages and twelve also underwent a sham session. Cerebral blood flow and oxyhemoglobin concentration increased during and after active stimulation in the region under the stimulation electrode while deoxyhemoglobin concentration decreased. The EEG spectrum displayed statistically significant power changes across different stimulation sessions in delta (2 to 4 Hz), theta (4 to 8 Hz), and beta (12 to 18 Hz) bands. Results suggest that fDCS and TR-fNIRS can be employed as neuromonitors of the effects of transcranial electrical stimulation and can be used together with EEG.