Reproductive aging: insights from model organisms.
Reproductive aging: insights from model organisms.
复制标题
生殖衰老：来自模式生物的见解。
DOI：
10.1042/bst20110694
复制
发表时间：
2011
影响因子：
3.9
通讯作者：
Bhalla,Needhi
中科院分区：
文献类型：
--
作者：
Ye,AliceL;Bhalla,Needhi
Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms and are potentially manipulable, suggesting the possibility of treatment for age-related disorders. Reproductive decline is one aspect of aging. In model organisms and humans of both sexes, increasing age is associated with both a decline in the number of progeny and an increased incidence of defects. The cellular mechanisms of reproductive aging are not well understood, although a number of factors, both intrinsic and extrinsic to an organism's germline, may contribute to aging phenotypes. Recent work in a variety of organisms suggests that nuclear organization and nuclear envelope proteins may play a role in these processes.
