Airway inflammation in iron ore miners exposed to dust and diesel exhaust
Airway inflammation in iron ore miners exposed to dust and diesel exhaust
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DOI：
10.1183/09031936.06.00034705
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发表时间：
2006-04-01
影响因子：
24.3
通讯作者：
Järvholm, B
中科院分区：
文献类型：
--
作者：
Ädelroth, E;Hedlund, U;Järvholm, B
本研究的目的是调查在铁矿接触粉尘和柴油废气的地下矿工是否会表现出呼吸道炎症的迹象，这反映在诱导痰中。总共对22名矿工进行了研究，第一次是在至少两周的假期之后，第二次是在正常工作3个月后。对照组为21名“白领”工人。所有受试者都完成了关于病史和职业史的问卷调查，并接受了肺功能测试和诱导痰收集。对诱导痰进行细胞总数和分类计数以及液体相分析。记录了个人接触元素碳、二氧化氮和可吸入粉尘的样本，可吸入粉尘、二氧化氮和元素碳的平均浓度分别为3.2 mg·m~(-3)、0.28 mg·m~(-3)和27 mg·m~(-3)。与对照组相比，矿工的炎症细胞数量增加，主要是肺泡巨噬细胞和中性粒细胞，诱导痰中纤维连接蛋白、金属蛋白酶-9和白介素10的浓度也增加。总体而言，地下铁矿的矿工表现出持续的呼吸道炎症，在4周假期后与在矿井下工作3个月后一样明显。
The aim of the present study was to investigate if underground miners exposed to dust and diesel exhaust in an iron ore mine would show signs of airway inflammation as reflected in induced sputum.In total, 22 miners were studied, once after a holiday of at least 2 weeks and the second time after 3 months of regular work. Control subjects were 21 "white-collar" workers. All subjects completed a questionnaire regarding medical and occupational history, and underwent lung function testing and induced sputum collection. Total and differential cell counts and analyses of the fluid phase of the induced sputum were performed. Sampling of personal exposure to elemental carbon, nitrogen dioxide and inhalable dust was recorded.The average concentrations of inhalable dust, nitrogen dioxide and elemental carbon were 3.2 mg(.)m(-3), 0.28 mg(.)m(-3) and 27 mu g(.)m(-3) respectively. Miners had increased numbers of inflammatory cells, mainly alveolar macrophages and neutrophils, and increased concentrations of fibronectin, metalloproteinase-9 and interleukin-10 in induced sputum compared with controls.In conclusion, miners in an underground iron ore mine demonstrated persistent airway inflammation that was as pronounced after a 4-week holiday as after a 3-month period of work underground in the mine.