Downregulation of N-cadherin Expression Inhibits Invasiveness, Arrests Cell Cycle and Induces Cell Apoptosis in Esophageal Squamous Cell Carcinoma
Downregulation of N-cadherin Expression Inhibits Invasiveness, Arrests Cell Cycle and Induces Cell Apoptosis in Esophageal Squamous Cell Carcinoma
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DOI：
10.3109/07357900903476745
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发表时间：
2010-06-01
影响因子：
2.4
通讯作者：
Fan, Qing-Xia
中科院分区：
文献类型：
--
作者：
Li, Ke;He, Wei;Fan, Qing-Xia
一些研究表明，N-钙粘蛋白在更具侵袭性的癌细胞系和肿瘤中表达上调，并在细胞间粘附中发挥关键作用。然而，人们对 N-钙粘蛋白在食管鳞状细胞癌（ESCC）中的作用的了解仍然很少。我们的数据表明，敲低食管鳞癌细胞系（EC9706）中的N-钙粘蛋白可以将细胞周期阻滞在G0/G1期，诱导细胞凋亡，减少体外侵袭性，并抑制体内肿瘤形成。这些结果表明N-cadherin是ESCC进展和转移的重要因素，N-cadherin可能作为ESCC生物治疗的潜在分子靶点。
Some studies have demonstrated that N-cadherin is upregulated in more invasive cancer cell lines and tumors and plays a key role in intercellular adhesion. However, the understanding on the roles N-cadherin plays in esophageal squamous cell carcinoma (ESCC) is still poor. Our data showed that knock-down of N-cadherin in ESCC cell line (EC9706) could arrest cell cycle at G0/G1 phase, induce cell apoptosis, reduce the invasiveness in vitro, and inhibit the tumor formation in vivo. These results suggest that N-cadherin is an important factor in the progression and metastasis of ESCC and N-cadherin may serve as a potential molecular target for biotherapy of ESCC.