Salivary flow rate and clinical characteristics of patients with xerostomia according to its aetiology
Salivary flow rate and clinical characteristics of patients with xerostomia according to its aetiology
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DOI：
10.1111/j.1365-2842.2009.02037.x
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Kho, H. -S.
中科院分区：
文献类型：
--
作者：
Cho, M. -A.;Ko, J. -Y.;Kho, H. -S.
本研究的目的是根据口干症的病因，探讨口干症患者在唾液流率和口干相关的主观症状和行为方面的差异。入选140例以口干症为主诉的患者(男24例，女116例，平均年龄58±13岁)。患者分为5组：干燥综合征组34例，头颈部放疗后组16例，抗精神病药物组30例，影响唾液流量的全身性疾病或药物组35例，病因不明组25例。这些患者被问到一系列关于口干的标准化问题，并测量了他们的整个唾液流率。有放射治疗病史的患者唾液流率下降最多，相关症状和行为最严重，而病因不明的患者唾液流率下降最少，症状和行为相对较好。口腔灼热感在系统性疾病患者或正在服药的患者中最常见，而味觉改变在服用抗精神病药物的患者中最常见。总而言之，口干症患者根据其病情的病因学表现出与生活质量相关的不同程度的不适。
P>The purpose of the present study was to investigate the differences in salivary flow rates and dry mouth-related subjective symptoms and behaviours in patients with xerostomia according to its aetiology. One hundred and forty patients (24 men and 116 women, mean age, 58 center dot 1 +/- 13 center dot 3 years) with a chief complaint of xerostomia were included. The patients were divided into five groups; Sjogren's syndrome (n = 34), post-radiation therapy in the head and neck region (n = 16), antipsychotic medications (n = 30), systemic diseases or medications affecting salivary flow (n = 35), and unknown aetiology (n = 25). The patients were asked a standardized series of questions concerning dry mouth, and their whole salivary flow rates were measured. Patients with a history of radiation therapy displayed the most decreased values of salivary flow rates and the most severe associated symptoms and behaviours while patients with unknown aetiology displayed the least decreased values of salivary flow rates and relatively favourable symptoms and behaviours. A burning sensation in the mouth was the most prevalent in patients with systemic diseases or those who were taking medications while altered taste perception was the most prevalent in patients taking antipsychotics. In conclusion, patients with xerostomia displayed various degrees of discomfort related to the quality of life according to the aetiology of their conditions.