Multiple components of lateral posterior parietal activation associated with cognitive set shifting
Multiple components of lateral posterior parietal activation associated with cognitive set shifting
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DOI：
10.1016/j.neuroimage.2004.12.063
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发表时间：
2005-07-01
期刊：
影响因子：
5.7
通讯作者：
Miyashita, Y
中科院分区：
文献类型：
--
作者：
Asari, T;Konishi, S;Miyashita, Y
在以前的神经影像学研究中，通常观察到后顶叶激活与认知集的灵活移动有关。然而，目前尚不清楚顶叶激活是否反映了转移本身固有的认知过程或其他混杂因素，如空间注意力。为了解决这个问题，威斯康星卡片分类任务（WCST）进行了修改，以便从任务的感觉和运动方面消除空间成分。此外，还引入了一个下一个维度的视觉指令来消除与下一个规则的试错识别相关的认知过程，并引入了一个控制零指令来消除指令线索的感知/古怪效应。使用视觉引导扫视任务的定位器扫描也被用于识别眼球运动/空间注意相关区域。在顶叶内区域的外侧部分显示了与试错相关的设定移动活动，而在顶叶内区域的内侧部分显示了与眼动/空间注意相关的活动，证实了双重分离对修正WCST的空间贡献很小。侧侧顶顶内活动是双侧的，但当将定向移位与无定向移位进行对比以进一步纯化移位相关活动时，左侧顶顶内活动明显大于右半球。这些结果揭示了左侧脑半球占优势的纯化移位相关活动在外侧后顶叶皮层，这可能与左侧脑半球占优势的外侧前额叶皮层合作。(c) 2005爱思唯尔公司版权所有。
Posterior parietal activation has commonly been observed in previous neuroimaging studies in association with flexible shifting of cognitive set. However, it is not clear whether the parietal activation reflects cognitive processes intrinsic to the shifting itself or other confounding factors such as spatial attention. To address this issue, the Wisconsin Card Sorting Task (WCST) was modified such that spatial components were eliminated from the sensory and motor aspects of the task. Moreover, a visual instruction of a next dimension was introduced to eliminate cognitive processes related to trial and error identification of a next rule, and a control null-instruction was also introduced to eliminate perceptual/oddball effects of the instruction cue. Localizer scans using a visually guided saccade task were also conducted to identify eye movement/spatial attention-related areas. Activity related to set shifting with trial and error was revealed in the lateral parts of the intraparietal regions, while activity related to eye movements/spatial attention was revealed in the medial parts of the intraparietal regions, confirming little spatial contribution to the modified WCST as indexed by the double dissociation. The lateral intraparietal activity was bilateral, but when the instructed shifting was contrasted with the null-instructed shifting to purify the shift-related activity further, the left intraparietal activation was significantly greater than that in the right hemisphere. These results reveal the left hemisphere dominance of purified shifting-related activity in the lateral posterior parietal cortex that may cooperate with the lateral prefrontal cortex whose left hemisphere dominance has already been reported. (c) 2005 Elsevier Inc. All rights reserved.