Intracellular cyclic adenosine 3',5'-monophosphate levels and streptomycin production in cultures of Streptomyces griseus.
Intracellular cyclic adenosine 3',5'-monophosphate levels and streptomycin production in cultures of Streptomyces griseus.
复制标题
灰色链霉菌培养物中细胞内环腺苷 3,5-单磷酸水平和链霉素产量。
DOI：
10.1139/m78-168
复制
发表时间：
1978
影响因子：
2.8
通讯作者：
L. Vining
中科院分区：
文献类型：
--
作者：
C. Ragan;L. Vining
当培养物在支持生长和链霉素合成的复杂培养基中经历营养期和分裂期时，测量灰色链霉菌菌丝体中环状3',5'-单磷酸腺苷含量的变化。在培养物进入稳定期之前浓度最高，并且在产生抗生素之前 5 小时浓度下降了 90%。当抗生素在自发相期间积累时，维持这种低浓度。结果表明，链霉素合成的开始并不是由细胞内环状3',5'-腺苷一磷酸浓度的增加直接介导的，因此灰色链霉菌中抗生素的产生不受分解代谢物抑制的控制。
Changes in the amount of cyclic 3',5'-adenosine monophosphate within the mycelium of Streptomyces griseus were measured as cultures progressed through trophophase and idiophase in a complex medium supporting growth and streptomycin synthesis. Concentrations were highest before the cultures entered stationary phase and had declined 90% by 5 h before the antibiotic was produced. This low conentration was maintained while the antibiotic accumulated during the idiophase. The results indicate that the onset of streptomycin synthesis is not directly mediated by an increase in intracellular cyclic 3',5'-adenosine monophosphate concentration, and thus that antibiotic production in S. griseus is not controlled by catabolite repression.