GABA(A) and GABA(C) receptors have contrasting effects on excitability in superior colliculus.
GABA(A) and GABA(C) receptors have contrasting effects on excitability in superior colliculus.
复制标题
GABA(A) 和GABA(C) 受体对上丘的兴奋性具有相反的作用。
DOI：
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发表时间：
1999
影响因子：
2.5
通讯作者：
M. Schmidt
中科院分区：
文献类型：
--
作者：
M. Pasternack;Mathias Boller;Belinda Pau;M. Schmidt
We have recently found that GABA(C) receptor subunit transcripts are expressed in the superficial layers of rat superior colliculus (SC). In the present study we used immunocytochemistry to demonstrate the presence of GABA(C) receptors in rat SC at protein level. We also investigated in acute rat brain slices the effect of GABA(A) and GABA(C) receptor agonists and antagonists on stimulus-evoked extracellular field potentials in SC. Electrical stimulation of the SC optic layer induced a biphasic, early and late, potential in the adjacent superficial layer. The late component was completely inhibited by 6-cyano-7-nitroquinoxaline-2,3-dione or CoCl(2), indicating that it was generated by postsynaptic activation. Muscimol, a potent GABA(A) and GABA(C) receptor agonist, strongly attenuated this postsynaptic potential at concentrations >10 microM. In contrast, the GABA(C) receptor agonist cis-aminocrotonic acid, as well as muscimol at lower concentrations (0.1-1 microM) increased the postsynaptic potential. This increase was blocked by (1,2,5, 6-tetrahydropyridine-4-yl)methylphosphinic acid, a novel competitive antagonist of GABA(C) receptors. Our findings demonstrate the presence of functional GABA(C) receptors in SC and suggest a disinhibitory role of these receptors in SC neuronal circuitry.
影响因子：
--
作者：
R. Mize
通讯作者：
R. Mize
影响因子：
3.6
作者：
D. Ragozzino;Richard M. Woodward;Y. Murata;F. Eusebi;Larry E. Overman;Ricardo Miledi
通讯作者：
D. Ragozzino;Richard M. Woodward;Y. Murata;F. Eusebi;Larry E. Overman;Ricardo Miledi
在大鼠视网膜中克隆 γ-氨基丁酸 C 型受体亚基，其蛋氨酸残基对印防己毒素通道阻断至关重要。
DOI：
10.1073/pnas.92.25.11756
发表时间：
1995
影响因子：
11.1
作者：
Zhang,D;Pan,ZH;Zhang,X;Brideau,AD;Lipton,SA
通讯作者：
Lipton,SA