Are p27 and p21 Cytoplasmic Oncoproteins?
Are p27 and p21 Cytoplasmic Oncoproteins?
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DOI：
10.4161/cc.1.6.262
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发表时间：
2002-11-01
期刊：
影响因子：
4.3
通讯作者：
Blagosklonny, Mikhail V.
中科院分区：
文献类型：
--
作者：
Blagosklonny, Mikhail V.
通过引起细胞质p27和p21的错位，Akt致癌激酶在功能上使这些核肿瘤抑制蛋白失活。p27和p21在细胞质中的定位仅仅等同于它们功能的丧失，还是在细胞质中获得了新的功能？事实上，一些证据表明细胞质p27和p21可能是具有抗凋亡活性的癌蛋白。
By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be oncoproteins with antiapoptotic activities.