A general method for the computer simulation of biological systems interacting with fluids.
A general method for the computer simulation of biological systems interacting with fluids.
复制标题
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
C. Peskin;D. McQueen
中科院分区：
文献类型：
--
作者：
C. Peskin;D. McQueen
在这次生物流体动力学研讨会上，有必要问一问，是否有任何共同的主题，统一在与流体相互作用的生命系统的研究中出现的各种问题。答案立即浮现在脑海中是这样的：生物流体动力学总是涉及弹性的柔性组织与粘性不可压缩流体的相互作用。(In在许多情况下，组织不仅是弹性的，而且是主动的，即能够对流体做功）。本文介绍了浸入边界法，这是一个通用的框架，计算机模拟的生物流体动力学系统。这种方法已经应用于心脏中的血流（包括人工心脏瓣膜的计算机辅助设计）、血液凝固期间的血小板聚集、水生动物运动、波沿内耳基底膜的沿着传播以及可折叠管中的流动。在浸没边界法中，弹性（和可能的活性）生物组织被视为流体的一部分，其中施加额外的力（来自组织应力）。因为组织是根据其力场来表示的，所以即使当生物组织的几何形状是复杂的、动态的并且事先不知道时，该方法仍然是简单的。
At this Symposium on Biological Fluid Dynamics, it is appropriate to ask whether there is any common theme that unites the diverse problems that arise in the study of living systems interacting with fluids. The answer that immediately comes to mind is this: biological fluid dynamics invariably involves the interaction of elastic flexible tissue with viscous incompressible fluid. (In many cases the tissue is not only elastic, it is also active, i.e. capable of doing work on the fluid). This paper describes the immersed boundary method, which is a general framework for the computer simulation of biofluid dynamic systems. This method has already been applied to blood flow in the heart (including the computer-assisted design of prosthetic cardiac valves), platelet aggregation during blood clotting, aquatic animal locomotion, wave propagation along the basilar membrane of the inner ear, and flow in collapsible tubes. In the immersed boundary method, the elastic (and possibly active) biological tissue is treated as a part of the fluid in which additional forces (derived from the tissue stresses) are applied. Because the tissue is represented in terms of its force field, the method remains straightforward, even when the geometry of the biological tissue is complicated, dynamic and not known in advance.