Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study
Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study
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DOI：
10.1016/j.maturitas.2018.11.001
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发表时间：
2019-01-01
期刊：
影响因子：
4.9
通讯作者：
Iki, Masayuki
中科院分区：
文献类型：
--
作者：
Jaalkhorol, Myadagmaa;Fujita, Yuki;Iki, Masayuki
目的：只有少数纵向研究评估了骨矿物质密度（BMD）与动脉硬化之间的关系。本研究旨在确定日本女性基线时的低 BMD 是否与动脉僵硬度增加相关，通过臂踝脉搏波速度 (baPWV) 进行评估。方法：采用 baPWV 值 >= 1800 cm/s 作为动脉僵硬度增加的标准，即研究结果。在完成基线调查的 725 名 50 岁以上女性中，我们排除了 166 名已经符合这一标准的女性。在其余女性中，我们分析了 446 名女性的数据，她们至少完成了一项在基线后 5 或 10 年后进行的后续调查。基线调查中采用双能X射线骨密度仪测量腰椎（LS）和全髋（TH）的BMD。 baPWV 在基线和随访时均进行测量。使用多变量逻辑回归来评估基线 BMD 对 10 年随访期间结果的独立影响。结果：我们确定了 166 名新出现动脉僵硬度增加的女性。调整年龄和收缩压后，LS 和 TH 时 BMD 降低 1 SD 即可得出结果的比值比 (OR) 分别为 1.20（95% 置信区间 [CI]：0.91-1.50）和 1.44（95% CI：1.14-1.81）。在基线时额外调整 baPWV 后，TH 时 BMD 降低 1 SD 的 OR 仍然显着（1.33，95% CI：1.02-1.72）。 结论：在对日本女性进行 10 年随访期间，TH 时低 BMD 与动脉僵硬度增加显着相关。
Objective: Only a few longitudinal studies have assessed the relationship between bone mineral density (BMD) and arteriosclerosis. This study aimed to determine whether low BMD at baseline is associated with the development of increased arterial stiffness, as evaluated by brachial-ankle pulse wave velocity (baPWV), in Japanese women.Methods: A baPWV value of >= 1800 cm/s was adopted as the criterion for increased arterial stiffness, i.e., the outcome of the study. Of the 725 women aged >= 50 years who completed the baseline survey, we excluded the 166 who already met this criterion. Of the remaining women, we analyzed data from the 446 who completed at least one of the follow-up surveys conducted 5 or 10 years after baseline. BMD at the lumbar spine (LS) and total hip (TH) was measured by dual-energy X-ray absorptiometry in the baseline survey. baPWV was measured both at baseline and at follow-up. Multivariate logistic regression was used to evaluate the independent effect of BMD at baseline on developing the outcome during 10-year follow-up.Results: We identified 166 women who newly developed increased arterial stiffness. The odds ratios (OR) for a 1 SD decrease in BMD at LS and TH for developing the outcome were 1.20 (95% confidence interval [CI]: 0.91-1.50), and 1.44 (95% CI: 1.14-1.81), respectively, after adjusting for age and systolic blood pressure. After additionally adjusting for baPWV at baseline, the OR for a 1 SD decrease in BMD at TH remained significant (1.33, 95% CI: 1.02-1.72).Conclusion: Low BMD at TH was significantly associated with the development of increased arterial stiffness during a 10-year follow-up of Japanese women.