Vitamin A levels and immunity in humans
Vitamin A levels and immunity in humans
复制标题
DOI：
10.1128/cdli.9.3.616-621.2002
复制
发表时间：
2002-05-01
期刊：
影响因子：
--
通讯作者：
Jarvis, WR
中科院分区：
文献类型：
--
作者：
Jason, J;Archibald, LK;Jarvis, WR
在动物实验中，维生素A缺乏导致2型（体液型）细胞因子向1型（细胞型）细胞因子转变；人类没有类似的数据。控制人类免疫缺陷病毒（HIV）和结核分枝杆菌感染需要I型细胞因子（细胞）免疫。这些感染和维生素A缺乏症在非洲非常普遍。因此，我们研究了血清维生素A水平、免疫参数、HIV感染状态、牛分枝杆菌卡介苗疤痕（作为I型细胞因子谱的指标）和非洲马拉维70名住院儿童的临床表现之间的相互作用。使用直接偶联单克隆抗体和流式细胞术评估外周血单核细胞和淋巴细胞亚群产生的细胞特异性细胞因子。采用的统计技术包括非参数统计和逻辑回归分析。30%的参与者严重缺乏维生素A（< 10杯/分升），34%的参与者中度缺乏维生素A（10杯/分升）
In animal studies, vitamin A deficiency induces a shift from type 2 (humoral) to type 1 (cellular) cytokines; there are no similar data for humans. Control of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis infections requires type I cytokine (cellular) immunity. These infections and vitamin A deficiency are highly prevalent in Africa. We therefore examined the interactions among serum vitamin A levels, immune parameters, HIV infection status, Mycobacterium bovis BCG vaccine scarring (as an indicator of a type I cytokine profile), and clinical findings for 70 hospitalized children in Malawi, Africa. Directly conjugated monoclonal antibodies and flow cytometry were used to assess cell-specific cytokine production by peripheral blood monocytes and lymphocyte subpopulations. The statistical techniques employed included nonparametric statistics and logistic regression analyses. Thirty percent of the participants had severe vitamin A deficiency (< 10 mug/dl), 34% had moderate deficiency (10 to