Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels
Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels
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DOI：
10.1067/mva.2002.119042
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发表时间：
2002-01-01
影响因子：
4.3
通讯作者：
Sillesen, H
中科院分区：
文献类型：
--
作者：
Gronholdt, MLM;Nordestgaard, BG;Sillesen, H
客观的。动脉粥样硬化可以被认为是一种以巨噬细胞为主的炎症性疾病。我们测试了颈动脉粥样硬化斑块中的巨噬细胞是否与 B 型超声成像的回声、脂质水平、炎症标志物和阿司匹林的使用相关。方法：我们研究了 106 名接受颈动脉内膜切除术的患者，这些患者有 50% 的颈动脉狭窄，并且既往有同侧半球神经系统症状。结果。巨噬细胞在脂质含量高和出血的斑块中特别常见，相反，在以钙化和纤维组织为主的斑块中则很少见。通过 B 型超声成像将颈动脉斑块中的巨噬细胞密度分类为透明 (n = 56)、中间 (n = 25) 或富含回声 (n = 25) 的密度分别为 1.8% +/- 0.2%、1.5% +/- 0.4% 和 1.0% +/- 0.2% (SE)（方差分析，P = .02）。计算机生成的斑块回声透明度测量值（灰度中值）与巨噬细胞密度增加相关（r = -0.31；P = .002）。此外，血浆和低密度脂蛋白胆固醇水平与颈动脉巨噬细胞密度相关（r = 0.26，P = .008 和 r = 0.23，P = .02），这在富含脂质斑块的患者中最为明显。巨噬细胞密度与急性期反应物的血浆水平无关。最后，服用阿司匹林的人 (n = 55) 和未服用阿司匹林的人 (n = 51) 的颈动脉斑块中的巨噬细胞密度分别为 1.2% +/- 0.2% 和 1.8% +/- 0.2%（t 检验，P = 0.01）。结论。颈动脉粥样硬化斑块中巨噬细胞密度的增加与脂质含量、斑块回声透明度以及血浆和低密度脂蛋白胆固醇水平的增加有关。此外，使用阿司匹林与颈动脉斑块中巨噬细胞密度降低有关。
Objective. Atherosclerosis may be regarded as an inflammatory disease dominated by macrophages. We tested whether macrophages in carotid artery atherosclerotic plaques are associated with echolucency on B-mode ultrasound imaging, lipid levels, inflammatory markers, and aspirin use.Methods: We studied 106 patients undergoing carotid endarterectomy having 50% carotid artery stenosis and previous ipsilateral hemispheric neurologic symptoms.Results. Macrophages were particularly common in plaques with a high content of lipid and hemorrhage and, conversely, rare in plaques dominated by calcification and fibrous tissue. Macrophage density in carotid artery plaques classified by B-mode ultrasound imaging as echolucent (n = 56), intermediate (n = 25), or echorich (n = 25) was 1.8% +/- 0.2%, 1.5% +/- +/- 0.4%, and 1.0% +/- 0.2% ( SE), respectively (analysis of variance, P = .02). A computer-generated measure of plaque echolucency, gray-scale median, was associated with increased macrophage density (r = -0.31; P = .002). Furthermore, plasma and low-density lipoprotein cholesterol levels were associated with carotid artery macrophage density (r = 0.26, P = .008 and r = 0.23, P = .02), this was most pronounced in patients with lipid-rich plaques Macrophage density was not associated with plasma levels of acute-phase reactants. Finally, macrophage density in carotid artery plaques of users (n = 55) and nonusers of aspirin (n = 51) was 1.2% +/- 0.2% and 1.8% +/- 0.2% (t test, P = .01).Conclusions. Increased macrophage density in carotid atherosclerotic plaques was associated with lipid content, plaque echolucency, and increased plasma and low-density lipoprotein cholesterol levels. Furthermore, use of aspirin was associated with reduced macrophage density in carotid artery plaques.