ALCOHOLIC HEPATOMEGALY - ACCUMULATION OF PROTEIN IN LIVER
ALCOHOLIC HEPATOMEGALY - ACCUMULATION OF PROTEIN IN LIVER
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DOI：
10.1126/science.1198096
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发表时间：
1975-01-01
期刊：
影响因子：
56.9
通讯作者：
LIEBER, CS
中科院分区：
文献类型：
--
作者：
BARAONA, E;LEO, MA;LIEBER, CS
长期摄入乙醇后出现的肝肿大会导致蛋白质的积累，其数量与脂质的增加同样重要。大部分蛋白质积聚在细胞的可溶部分中。肝白蛋白和转铁蛋白浓度增加，秋水仙碱结合蛋白减少，因此表明输出蛋白在肝内滞留。
The hepatomegaly that appears after long-term feeding of ethanol results in accumulation of protein that is quantitatively as important as the increase in lipid. The bulk of protein accumulates in the soluble fraction of the cell. Hepatic albumin and transferrin concentrations increase and colchicine-binding protein decreases, thus suggesting an intrahepatic retention of export proteins.