A wireless remote high-power laser device for optogenetic experiments
A wireless remote high-power laser device for optogenetic experiments
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DOI：
10.1088/1054-660x/25/4/045601
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发表时间：
2015-04
期刊：
影响因子：
1.2
通讯作者：
Y. Wang;Q. Gong;Y. Li;A. Z. Li;Y. Zhang;C. Cao;H. Xu;J. Cui;J. J. Gao-J.
中科院分区：
文献类型：
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作者：
Y. Wang;Q. Gong;Y. Li;A. Z. Li;Y. Zhang;C. Cao;H. Xu;J. Cui;J. J. Gao-J.
光遗传学提供了以相对无害的方式刺激遗传靶向神经元的能力。可靠和有针对性的工具使神经系统研究中的多功能新类别的调查成为可能。然而，当前的硬件系统通常限于急性测量或需要系统到光源的外部系链。在这里，我们为光遗传学在神经科学中的应用提供了一种低成本，高功率，远程控制的蓝色激光二极管（LD）刺激器，专注于可穿戴和智能设备，可由猴子，大鼠和任何其他研究动物携带。与传统的发光二极管（LED）器件相比，该LD刺激器具有更高的效率、输出功率和稳定性。我们的系统是完全无线控制的，适合大量动物的实验。
Optogenetics affords the ability to stimulate genetically targeted neurons in a relatively innocuous manner. Reliable and targetable tools have enabled versatile new classes of investigation in the study of neural systems. However, current hardware systems are generally limited to acute measurements or require external tethering of the system to the light source. Here we provide a low-cost, high-power, remotely controlled blue laser diode (LD) stimulator for the application of optogenetics in neuroscience, focusing on wearable and intelligent devices, which can be carried by monkeys, rats and any other animals under study. Compared with the conventional light emitting diode (LED) device, this LD stimulator has higher efficiency, output power, and stability. Our system is fully wirelessly controlled and suitable for experiments with a large number of animals.