Immediate Evaluation of Neovascularization in a Grafted Bilayered Artificial Dermis Using Laser Doppler Imaging
Immediate Evaluation of Neovascularization in a Grafted Bilayered Artificial Dermis Using Laser Doppler Imaging
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DOI：
10.1097/sap.0b013e3182590948
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发表时间：
2014-01-01
影响因子：
1.5
通讯作者：
Suzuki, Shigehiko
中科院分区：
文献类型：
--
作者：
Morimoto, Naoki;Takemoto, Satoru;Suzuki, Shigehiko
背景：双层人工真皮被广泛应用于皮肤缺损。其胶原海绵被生物降解，使用后被真皮样组织取代。目前还没有可靠的方法来定量评价人工真皮的血流量。本研究应用激光多普勒成像技术评价人工真皮的血流灌注情况。材料和方法：12例患者接受了人工真皮和二次植皮。分别在应用人工真皮后、术后1周、植皮前测量灌注单位。结果：6例患者二期植皮完全成活，其余患者出现部分坏死。激光多普勒成像可以检测到人工真皮内的血流，移植前“完全取用”组和“部分坏死”组的血流灌注单位有显著差异(P<；0.05)。结论：激光多普勒成像是一种有用的、无创性的移植前评价人工真皮血流的技术。
Background: A bilayered artificial dermis is widely applied for skin defects. Its collagen sponge is biodegraded and replaced with dermis-like tissue after application. There is no reliable method for quantitatively evaluating the blood flow of artificial dermis. In this study, we used laser Doppler imaging to evaluate the perfusion of artificial dermis.Materials and Methods: Twelve patients treated with artificial dermis and secondary skin grafting were included. We measured the perfusion unit just after application of artificial dermis, 1 week after, and before skin grafting.Results: Secondary skin grafts of 6 patients took completely, and the others showed partial necrosis. Laser Doppler imaging could detect blood flow in the artificial dermis, and a significant difference was observed in perfusion units between the "omplete take'' group and "partial necrosis'' group before grafting (P < 0.05).Conclusions: Laser Doppler imaging could be a useful and noninvasive technique for the evaluation of blood flow to the artificial dermis before grafting.