Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract
Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract
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DOI：
10.1016/j.febslet.2005.05.050
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发表时间：
2005-07-04
期刊：
影响因子：
3.5
通讯作者：
Renshaw, SA
中科院分区：
文献类型：
--
作者：
Dempsey, CE;Dive, C;Renshaw, SA
促凋亡Bcl-2家族蛋白的表达减少已在许多胃肠道癌症中被描述，并可能在肿瘤发生中发挥作用。促凋亡Bcl-2蛋白的人类同源物Bfk主要在胃肠道组织中表达。在结肠中，鉴定出四种选择性剪接的异构体；其中两种在过表达时促凋亡。在从正常组织向肿瘤的转变过程中，与胃肠道外肿瘤的3/117相比，从人类胃肠道分离的肿瘤（8110个结肠肿瘤和26/37的胃肠道肿瘤）中多达80%的促凋亡Bfk亚型表达显著降低。这些数据表明，促凋亡的Bfk亚型可能有助于防止人类胃肠道恶性肿瘤的发展。(c) 2005年欧洲生化学会联合会。Elsevier B.V.版权所有。
Reduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8110 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.