Hematopoietic Stem Cells and Their Niche
Hematopoietic Stem Cells and Their Niche
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DOI：
10.1007/978-1-60327-347-3_2
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发表时间：
2017
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干细胞的主要功能（即，多能性和自我更新）是维持器官终身功能的关键。干细胞存在于一个特殊的微环境中，称为niche。小生境和干细胞通过粘附分子相互粘附，并交换维持干细胞特征的分子信号。在本章中，以造血系统为例，说明干细胞与其生态位之间的相互作用，这是研究最深入和最典型的干细胞系统。解释了不同种类的生态位和调节机制。此外，还讨论了肿瘤干细胞小生境参与肿瘤干细胞调节、肿瘤侵袭和转移，以及与肿瘤干细胞小生境相关的新治疗方法。
The stem cells’ major capabilities (i.e., the pluripotency and the self-renewal) are the keys to sustain the lifelong functionality of the organ. Stem cells reside in the special microenvironment called niche. The niche and stem cells adhere to each other via adhesion molecules and exchange the molecular signals that maintain the stem cell features. It has been suggested that tumor tissue also contains such type of cells.In this chapter, the hematopoietic system is exemplified to show the interaction between the stem cell and its niche, which is the most intensively studied and archetypical stem cell system. Different kinds of niche and the regulatory mechanisms are explained. Furthermore, the niche involvement in cancer stem regulation, tumor invasion, and metastasis, as well as the novel therapeutic approaches in association with the cancer stem cell niche are also discussed.