Prevalence of adult-onset multifactorial disease among offspring of atomic bomb survivors
Prevalence of adult-onset multifactorial disease among offspring of atomic bomb survivors
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DOI：
10.1667/rr1392.1
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发表时间：
2008-10-01
影响因子：
3.4
通讯作者：
Shore, R. E.
中科院分区：
文献类型：
--
作者：
Fujiwara, S.;Suyama, A.;Shore, R. E.
第一项研究是检查父母的辐射暴露是否会导致常见的成人发病多因素疾病（即，高血压、糖尿病、高胆固醇血症、缺血性心脏病和中风）在临床检查项目的11，951名参与者中进行，这些参与者是1946年5月至1984年12月出生的幸存者的后代的24，673名潜在邮件调查对象。Logistic回归分析表明，在调整年龄、城市、性别和各种风险因素后，没有证据表明后代多因素疾病的患病率与父母的辐射暴露之间存在关联。父亲剂量为1戈伊的比值比（OR）为0.91 [95%置信区间（CI）0.81-1.01，P = 0.08]。母体剂量为1戈伊时的敏感性为0.98（95% CI 0.86-1.10，P = 0.71）。有没有明显的影响，父母的年龄在曝光或父母之间的曝光和出生的时间，但男性后代有一个较低的比值比（OR = 0.76，在1戈伊）的父亲曝光，但谨慎的解释是必要的这一发现。对近12 000名中位年龄约为50岁的原子弹爆炸幸存者的后代进行的临床评估没有提供证据表明，成年人发病的多因素疾病的发病率增加与父母的辐射照射有关。(C)2008年，辐射研究协会。
The first study to examine whether parental radiation exposure leads to increased heritable risk of common adult-onset multifactorial diseases (i.e., hypertension, diabetes mellitus, hypercholesterolemia, ischemic heart disease, and stroke) was conducted among 11,951 participants in the clinical examination program out of a potential of 24,673 mail survey subjects who were offspring of survivors born from May 1946 through December 1984. Logistic regression analyses demonstrated no evidence of an association between the prevalence of multifactorial diseases in the offspring and parental radiation exposure, after adjusting for age, city, gender and various risk factors. The odds ratio (OR) for a paternal dose of 1 Gy was 0.91 [95% confidence interval (CI) 0.81-1.01, P = 0.08]. and that for a maternal dose of 1 Gy was 0.98 (95% CI 0.86-1.10, P = 0.71). There was no apparent effect of parental age at exposure or of elapsed time between parental exposure and birth, but male offspring had a low odds ratio (OR = 0.76 at 1 Gy) for paternal exposure, but cautious interpretation is needed for this finding. The clinical assessment of nearly 12,000 offspring of A-bomb survivors who have reached a median age of about 50 years provided no evidence for an increased prevalence of adult-onset multifactorial diseases in relation to parental radiation exposure. (C) 2008 by Radiation Research Society.