Spontaneous lesions in aged captive raccoons (Procyon lotor).
Spontaneous lesions in aged captive raccoons (Procyon lotor).
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老年圈养浣熊（Procyon Lotor）的自发损伤。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
A. Hamir
中科院分区：
文献类型：
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作者：
A. Hamir
在自然界中，自由放养的浣熊通常活不过2岁；大多数野生浣熊都死于意外事故和疾病。因此，关于浣熊衰老相关病变的数据很少。本通讯记录了在爱荷华州中部一个商业设施中作为繁殖者的7岁以上的浣熊（7只公浣熊，3只母浣熊）中出现的病变。这些浣熊最常见的显微镜病变包括肝脏和脾脏中铁色素的积累（10 / 10），尾髓神经轴突变性（10 / 10），脉络膜丛血管矿化（沙粒体）（9 / 10），心肌包涵体（7 / 8）和囊性子宫内膜增生（2 / 3）。其他情况的患病率较低。除1只貉胃黏膜检出细菌性胃炎、3只脉络膜丛内发现炎性细胞、1只脑内发现拉福拉小体外，其余均为貉既往报道。令人惊讶的是，以前在老年圈养浣熊中观察到的常见偶然发现的胰岛细胞淀粉样变，在我们检查的任何浣熊中都没有发现。由于自由放养的浣熊分布在广阔的地理区域，其当地环境可能对从特定地点获得的浣熊发生的自发病变范围有相当大的影响。因此，在爱荷华州中部这些浣熊身上发现的病变可能与其他浣熊种群不同。
In nature, free-ranging raccoons typically do not live longer than 2 y; most raccoons in the wild die young due to accidents and diseases. Therefore, few data are available regarding lesions associated with advancing age in raccoons. This communication documents the lesions present in raccoons (7 male; 3 female) that were older than 7 y and had been used as breeders at a commercial facility in central Iowa. The most frequent microscopic lesions in these raccoons included accumulation of iron pigment in livers and spleens (10 of 10 animals evaluated), neuroaxonal degeneration in caudal medulla (10 of 10), vascular mineralization (psammoma body) in choroid plexus (9 of 10), myocardial inclusions (7 of 8), and cystic endometrial hyperplasia (2 of 3). Other conditions were seen with less prevalence. Except for the detection of gastritis with bacteria in the gastric mucosa of 1 raccoon, the presence of inflammatory cells in 3 choroid plexuses, and the presence of Lafora bodies in the brain of 1 animal, all conditions observed had previously been reported in raccoons. Surprisingly, islet-cell amyloidosis, previously observed as common incidental finding in older captive raccoons, was not seen in any of the raccoons we examined. Because free-ranging raccoons are distributed over wide geographic areas, their local environment may have considerable influence on the range of spontaneous lesions that would occur in raccoons obtained from a specific location. Therefore, the lesions found in these raccoons from central Iowa may differ from those of other raccoon populations.